Think about where your body goes and how your doors open and close when you choose a drawer setup.
A single, wide drawer that opens out from your side or rear cargo doors might make it tough to reach things.
For instance, a drawer that takes up the width of your side cargo opening won't allow you to stand next to the drawer if you have swing doors (not a problem with a slider).
So, with doors that don't open very far (like side cargo doors), it might be very difficult to reach items at the back of a drawer, even if the drawer is fully extended.